CYANOCOBALAMIN (VITAMIN B12)
Siffa da Halaye
Wannan samfurin foda ne mai launin ja ko crystalline, ba shi da ƙamshi, ba shi da ɗanɗano kuma yana da ƙarfi mai haifar da danshi. Yana narkewa kaɗan a cikin ruwa ko ethanol, ba ya narkewa a cikin chloroform ko ether. Yana jure zafi, amma yana iya zama mara tasiri idan aka fallasa shi ga abubuwa masu lalata ko rage iska, gishirin ƙarfe mai nauyi da acid mai ƙarfi da alkalis mai ƙarfi.
Tsarin Sinadarai
Vitamin B12 wani sinadari ne mai kama da equioctaphedral wanda ke ɗauke da ions na cobalt. Tsarinsa na tsakiya shine zoben corrin mai faɗi wanda ya ƙunshi pyrroles guda huɗu da aka haɗa. Kwayoyin bitamin B12 sun ƙunshi kusan sassa 3: zoben gourin da aka haɗa da ƙwayoyin N guda huɗu da ions na cobalt na tsakiya; 5,6-dimethylbenzimidazole wanda aka haɗa da ƙwayoyin N-7 da ions na cobalt a matsayin ƙwayoyin bitamin B 12 na ƙananan ligands. Bugu da ƙari, DMBI kuma an haɗa shi da aminopropanol ta hanyar ƙungiyoyin phosphate, kuma aminopropanol yana da alaƙa da sarkar gefen propionic acid akan pyrrole D; ƙungiyar adenosyl ko ƙungiyar methyl. Yana da alaƙa da ions na cobalt don samar da babban ligand na ƙwayoyin bitamin B12.
Aikin Halittar Jiki
Rashin bitamin B12 na iya haifar da ciwon jijiyoyi na gefe. Alamun farko na rashin bitamin B12 a cikin yara sune yanayi mara kyau, rashin saurin amsawa, jinkirin amsawa, kuma a ƙarshe yana haifar da rashin jini. Yana haɓaka ci gaba da balaga na ƙwayoyin jinin ja. Ana canza Methylpropandiyl coenzyme A zuwa succinoyl coenzyme A kuma yana shiga cikin zagayowar tricarboxylic acid, wanda succinyl coenzyme A ke da alaƙa da haɗa heme. Vitamin B12 kuma yana shiga cikin haɗa deoxynucleic acid (DNA), metabolism na mai, carbohydrates da furotin, kuma yana ƙara haɗa nucleic acid da sunadarai.
